First recorded by Larry Clinton & His Orchestra with Bea Wain (US #1 February 1939).
Other hit versions by Eddy Duchin (US #12 1939), Al Donahue & His Orchestra (US #16 1939), The Four Aces (US #11 1952), Jan & Dean (US #25 1961), The Cleftones (US #18 1961).
From the wiki: “‘Heart and Soul’ was written by Hoagy Carmichael (‘Stardust‘, ‘Georgia on My Mind‘) with lyrics by Frank Loesser and first recorded in 1938 by Larry Clinton & His Orchestra featuring Bea Wain. In 1939, three versions charted: Larry Clinton (reaching #1 on the chart in February, 1939), Eddy Duchin (reaching #12), and Al Donahue (reaching #16).
“The Four Aces covered and charted ‘Heart and Soul’ in 1952. Two contrasting cover versions charted in 1961: surfers Jan & Dean reachedg #25, while the Cleftones reached #18 with a neo-doo wop arrangement. The Cleftones’ recording became more widely and popularly known after it was used in the 1972 movie American Graffiti, and was included on the soundtrack album.